Negative feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling
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چکیده
منابع مشابه
Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling.
Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2014
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.159145